Molecular docking analysis of Bcl-2 with phytocompounds
Ponnulakshmi Rajagopal
Abstract
The Bcl-2 protein is liked in several cancers and drug resistance to therapy is also known in this context. There are many Bcl-2 inhibitors under clinical trials. It is of further interest to design new Bcl2 inhibitors from phyto compounds such as artesunate, bruceantin, maytansin, Salvicine, indicine N-oxide, kamebanin and oxyacanthine. We report the optimal binding features of these compounds with Bcl-2 for further consideration towards in vitro and in vivo validation.
Topics & Concepts
Docking (animal)In vivoPharmacologyContext (archaeology)Computational biologyMedicineBiologyBiotechnologyVeterinary medicinePaleontologyBioactive Compounds and Antitumor AgentsSynthesis and biological activityToxin Mechanisms and Immunotoxins