C3-selective C–H thiolation of quinolines <i>via</i> an <i>N</i>-arylmethyl activation strategy
Shun Li, Juan Tang, Yi-Hua Fu, Xueli Zheng, Maolin Yuan, Rui-Xiang Li, Zhishan Su, Haiyan Fu, Hua Chen
Abstract
Metal-free selective C–H thiolation of quinoline, including trifluoromethyl thiolation, aryl thiolation, alkyl thiolation and phenyl selenylation, using N -arylmethyl activation strategies is reported and is applicable to quinoline-based biologically active complex molecules.
Topics & Concepts
ChemistryQuinolineTrifluoromethylAlkylArylCombinatorial chemistryStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesFluorine in Organic Chemistry