Upregulated NMDAR-enhanced GABAergic transmission underlies autistic-like deficits in <i>Htr3a</i> knockout mice
Lang Huang, Jing Wang, Guanmei Liang, Yue Gao, Shiyang Jin, Jian Hu, Xiaoxue Yang, Jianpei Lao, Jinfa Chen, Zhou-Cai Luo, Cui-Xia Fan, Li Xiong, Xinhong Zhu, Tianming Gao, Mei Zhong, Xinping Yang
Abstract
deficiency. Therefore, we suggest that the NMDAR system could be considered potential therapeutic target for autism.
Topics & Concepts
GABAergicNeuroscienceBiologyDownregulation and upregulationNeurotransmissionInhibitory postsynaptic potentialReceptorGeneticsGeneAutism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNuclear Receptors and Signaling