Association of β-Lactam Allergy Documentation and Prophylactic Antibiotic Use in Surgery: A National Cross-Sectional Study of Hospitalized Patients
Christie M Bertram, Michael Postelnick, Christian Mancini, Xiaoqing Fu, Yuqing Zhang, Lucas Schulz, Tanaya Bhowmick, Francesca Lee, Kimberly G. Blumenthal
Abstract
Alternative antibiotics for surgical prophylaxis are associated with increased adverse events and surgical site infection compared to cefazolin. In a sample of perioperative inpatients from 100 hospitals in the United States, cefazolin was 9-fold less likely to be used in patients with a documented β-lactam allergy whereas clindamycin was 45-fold more likely.
Topics & Concepts
CefazolinMedicinePerioperativeAntibioticsClindamycinCross-sectional studyAllergyAntibiotic prophylaxisAdverse effectSurgeryInternal medicineImmunologyPathologyMicrobiologyBiologyDrug-Induced Adverse ReactionsSurgical site infection preventionAntibiotics Pharmacokinetics and Efficacy