Ligand-accelerated site-selective Csp<sup>2</sup>–H and Csp<sup>3</sup>–H alkynylations of alcohols <i>via</i> Pd(<scp>ii</scp>) catalysis
Aidong Huang, Yishen Han, Peiqing Wu, Yang Gao, Yanping Huo, Qian Chen, Xianwei Li
Abstract
A ligand accelerated site-selective C–H alkynylation, including secondary and tertiary Csp 3 –H alkynylation of weakly coordinated yet synthetically promising alcohols, via putative 6, 7 and 8-membered palladacycle intermediates, was developed.
Topics & Concepts
ChemistryLigand (biochemistry)AlkynylationCatalysisCombinatorial chemistryMedicinal chemistryOrganic chemistryBiochemistryReceptorCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsCatalytic Cross-Coupling Reactions