Deficiency of the X-inactivation escaping gene <i>KDM5C</i> in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis
Qian Zheng, Pengfei Li, Xin Zhou, Yulong Qiang, Jiachen Fan, Yan Lin, Yurou Chen, Jing Guo, Fan Wang, Haihua Xue, Jie Xiong, Feng Li
Abstract
This work revealed that a histone modifier gene inactive mutation reprogramed glycogen metabolism and helped to explain the long-standing puzzle of male predominance in human cancer. In addition, our findings may suggest the therapeutic value of targeting glycogen metabolism in ccRCC.
Topics & Concepts
Clear cell renal cell carcinomaBiologyDemethylaseAdenine phosphoribosyltransferaseHMOX1HistoneGeneticsBiochemistryGeneInternal medicineRenal cell carcinomaPurineHemeHeme oxygenaseEnzymeMedicineEpigenetics and DNA MethylationRNA modifications and cancerCancer-related gene regulation