The combination of sodium alginate and chlorogenic acid enhances the therapeutic effect on ulcerative colitis by the regulation of inflammation and the intestinal flora
Wei Niu, Yuxuan Chen, Ligui Wang, Jia Li, Zhao Cui, Jiajie Lv, Fuyan Yang, Jiege Huo, Zhenhai Zhang, Jianming Ju
Abstract
Thus, CA plus SA can improve the therapeutic efficacy of CA in UC by regulating inflammatory factors, oxidative stress, and the intestinal flora and by protecting ulcerative wounds. These findings broaden our understanding of the role of the combination of SA and CA in enhancing the effects of CA on UC and provide strategies for prevention and treatment.
Topics & Concepts
Ulcerative colitisMyeloperoxidaseSuperoxide dismutaseBacteroides fragilisChemistryNitric oxidePharmacologyColitisInflammationBacteroidesOxidative stressMicrobiologyImmunologyMedicineInternal medicineBiochemistryBiologyBacteriaAntibioticsDiseaseGeneticsOrganic chemistryInflammatory Bowel DiseaseGut microbiota and healthPharmacological Effects of Natural Compounds