Rh(I)‐Catalyzed Direct C6−H Arylation of 2‐Pyridones with Aryl Carboxylic Acids
Haoqiang Zhao, Jianbin Xu, Xin Xu, Yixiao Pan, Zexin Yu, Lijin Xu, Qing‐Hua Fan, Patrick J. Walsh
Abstract
Abstract A Rh(I)‐catalyzed C6‐selective C−H arylation of 2‐pyridones with inexpensive, readily available, safe and structurally diverse aryl carboxylic acids with the aid of a pyridine directing group is developed. This decarbonylative arylation protocol features an easy‐to‐handle catalytic system, and is amenable to diversely substituted 2‐pyridones and aryl carboxylic acids. It allows access to a wide range of C6‐arylated 2‐pyridones, including those that are difficult to prepare using conventional C−H arylation processes. The method tolerates various electron‐neutral, electron‐rich and electron‐deficient functional groups, and affords the products in 41–91% yields. magnified image