Visible-Light-Induced Synergistic W/Cr Catalyzed <i>gem</i>-Difluoroallylation of Unactivated Alkanes
Zhijie Zhang, Yue Zhang, Xinyu Xie, Huawei Liu, Tianshuai Zhu, Jing‐Jing Zhang, Mengyang Hu, Zhen Chen
Abstract
Currently, the scope of the Nozaki–Hiyama–Kishi (NHK) reaction is limited to aldehydes and ketones to construct alcohol derivatives. Herein, we have described a visible-light-induced synergistic W/Cr(III)-catalyzed NHK-type gem -difluoroallylation reaction of unactivated cyclic and linear alkanes. The reaction merits feedstock materials, mild reaction conditions, and a wide functionality tolerance. Mechanistic studies imply the favorable reduction of CrCl 3 to CrCl 2 by reduced decatungstate W 10 O 32 5–, thus closing the catalytic cycle.
Topics & Concepts
ChemistryCatalysisPhotochemistryVisible spectrumCombinatorial chemistryMedicinal chemistryOrganic chemistryOptoelectronicsPhysicsFluorine in Organic ChemistryRadical Photochemical ReactionsInorganic Fluorides and Related Compounds