Gut lactate increases circulating <scp>l</scp> -Lac-Phe and key metabolites linked to GLP-1 and human health
Emaan Ghias, Mette Glavind Bülow Pedersen, Camilla Bak Nielsen, Louise Vase Bech, Ida Marie Modvig, Natasa Brkovic Zubanovic, Jacob Marthinsen Seefeldt, Roni Nielsen, Esben Søndergaard, Kim Frisch, Jakob Bondo Hansen, Jens J. Holst, Niels Møller, Nikolaj Rittig, Mogens Johannsen
Abstract
By investigating the effects of oral versus IV lactate administration, we find that oral lactate elevates plasma l-lactate and strongly increases circulating l-Lac-Phe and l-Lac-Val, potentially via an alternative mechanism than exercise-induced formation. Furthermore, we find that GLP-1 secretion is not directly induced by lactate but may be mediated via increased bile acids and SCFAs in the gut.
Topics & Concepts
MetabolomeMetaboliteMetabolomicsAmino acidBiochemistryBiologyChemistryInternal medicineBioinformaticsMedicineDiet and metabolism studiesMetabolism, Diabetes, and CancerMetabolomics and Mass Spectrometry Studies