Long noncoding RNAs may impact podocytes and proximal tubule function through modulating miRNAs expression in Early Diabetic Kidney Disease of Type 2 Diabetes Mellitus patients
Ligia Petrică, Elena Hogea, Florica Gădălean, Adrian Vlad, Mihaela Vlad, Victor Dumitraşcu, Silvia Velciov, Cristina Gluhovschi, Flaviu Bob, Sorin Ursoniu, Dragoş Cătălin Jianu, Petru Matusz, Agneta-Maria Pusztai, Andrei Gheorghe Marius Motoc, Octavian Creţu, Dana M. Radu, Oana Milaş, Alina Golea-Secara, Anca Suteanu‐Simulescu, Maria Mogos-Stefan, Mihaela Patruica, Lavinia Balint, Silvia Ienciu, Mihaela Vlad, Roxana Popescu
Abstract
Aims: Long noncoding RNAs (lncRNAs) play key roles in the pathophysiology of DKD involving actions of microRNAs (miRNAs). The aims of the study were to establish the involvement of selected lncRNAs in the epigenetic mechanisms of podocyte damage and tubular injury in DKD of type 2 diabetes mellitus (DM) patients in relation to a particular miRNAs profile. Methods: A total of 136 patients with type 2 DM and 25 healthy subjects were assessed in a cross-sectional study concerning urinary albumin: creatinine ratio (UACR), eGFR, biomarkers of podocyte damage (synaptopodin, podocalyxin) and of proximal tubule (PT) dysfunction (Kidney injury molecule-1-KIM-1, N-acetyl-D-glucosaminidase-NAG), urinary lncRNA metastasis-associated lung adenocarcinoma transcript 1