Metal‐Free Direct C3−H Alkylation and Arylation of Quinoxalin‐2(1<i>H</i>)‐Ones with Inert Alkyl and Aryl Chlorides
Alisha Rani Tripathy, Ashutosh Mishra, Vesaj Singh, Veera Reddy Yatham
Abstract
In the present manuscript, we reported the first visible-light-enabled direct C3-H alkylation/arylation of quinoxalin-2(1H)-ones with unactivated alkyl/aryl chlorides under metal-free conditions. A wide range of unactivated alkyl and aryl chlorides containing different functionalities are coupled with a variety of quinoxalin-2(1H)-one derivatives under mild reaction conditions to afford the C3-alkyl/aryl substituted quinoxalin-2(1H)-ones in moderate to good yields.
Topics & Concepts
AlkylAlkylationArylChemistryMetalInertMedicinal chemistryOrganic chemistryCatalysisRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions