A Population Pharmacokinetic Analysis of Continuous Infusion of Cloxacillin during <i>Staphylococcus aureus</i> Bone and Joint Infections
Johan Courjon, Margaux Garzaro, Pierre‐Marie Roger, Raymond Ruimy, Thibaud Lavrut, Mikaël Chelli, Jean-Luc Raynier, David Chirio, Élisa Demonchy, Laura Cabane, F. Jehl, Christophe Trojani, Antoine Grillon, Sylvain Goutelle
Abstract
Intravenous administration of antibiotics is recommended during the early phase of methicillin-susceptible S. aureus (MSSA) bone and joint infection (BJI). We sought to compare the plasma concentrations of cloxacillin administered alternately by continuous and intermittent infusion (CI and ItI) in patients with MSSA BJI. In this prospective crossover trial, patients were randomly assigned to receive either 3 days of CI (two 75-mg/kg 12-h cloxacillin infusions per day) and then 3 days of ItI (four 37.
Topics & Concepts
CloxacillinMedicineStaphylococcus aureusAntibioticsCrossover studyPharmacokineticsJoint infectionsMicrococcaceaePopulationAnesthesiaProspective cohort studySurgeryAntibacterial agentInternal medicineMicrobiologyArthroplastyBiologyPeriprostheticAlternative medicinePlaceboBacteriaEnvironmental healthPathologyPenicillinGeneticsAntimicrobial Resistance in StaphylococcusAntibiotics Pharmacokinetics and EfficacyOrthopedic Infections and Treatments