Silver-Catalyzed <i>para</i>-Selective Amination and Aminative Dearomatization of Phenols with Azodicarboxylates in Water
Ruinan Zhao, Zhong Yuan Zhou, Jixiang Liu, Xia Wang, Qian Zhang, Dong Li
Abstract
An efficient silver-catalyzed para-selective amination and aminative dearomatization of phenols with azodicarboxylates was developed. It afforded the para-aminophenols or amino cyclohexadieneones from free phenols depending on whether it has a para-substituent. The reaction proceeded smoothly in water under simple and mild conditions, giving the highly selective products in good yields within a short reaction time. It also showed broad substrate scope and good functional group compatibility.
Topics & Concepts
ChemistryAminationPhenolsSubstituentCatalysisOrganic chemistryCompatibility (geochemistry)Substrate (aquarium)Combinatorial chemistryFunctional groupReaction conditionsChemical engineeringPolymerOceanographyGeologyEngineeringCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsSynthesis and Catalytic Reactions