Design, synthesis, and biological evaluation of novel pyrazolo [3,4-d]pyrimidine derivatives as potent PLK4 inhibitors for the treatment of TRIM37-amplified breast cancer
Yin Sun, Yu Sun, Lin Wang, Tianxiao Wu, Wenbo Yin, Jingkai Wang, Yanli Xue, Qiaohua Qin, Yixiang Sun, Huali Yang, Dongmei Zhao, Maosheng Cheng
Topics & Concepts
ChemistryPyrimidineKinaseLead compoundIC50In vivoCancerCancer cellBiochemistryPharmacologyIn vitroBiologyGeneticsBiotechnologyCancer Mechanisms and TherapyCancer therapeutics and mechanismsinterferon and immune responses