Design, synthesis and anticancer evaluation of new 4-anilinoquinoline-3-carbonitrile derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers
Min Zou, Jiawen Li, Bo Jin, Ming‐Sheng Wang, Huiping Chen, Zhuangli Zhang, Changzheng Zhang, Zhihong Zhao, Liyun Zheng
Topics & Concepts
ChemistryLapatinibNeratinibIC50StereochemistryDocking (animal)Cell cycle checkpointApoptosisPharmacologyCell cycleBiochemistryIn vitroCancerTrastuzumabBreast cancerInternal medicineMedicineNursingHER2/EGFR in Cancer ResearchSynthesis and biological activityLung Cancer Treatments and Mutations