Enhancing Neuraminidase Immunogenicity of Influenza A Viruses by Rewiring RNA Packaging Signals
Allen Zheng, Weina Sun, Xiaoli Xiong, Alec W. Freyn, Julia Peukes, Shirin Strohmeier, Raffael Nachbagauer, John A. G. Briggs, Florian Krammer, Peter Palese
Abstract
Influenza virus infections are a major source of morbidity and mortality worldwide. Increasing evidence highlights neuraminidase as a potential vaccination target. This report demonstrates the efficacy of rewiring influenza virus packaging signals for creating vaccines with more neuraminidase content which provide better neuraminidase (NA)-based protection.
Topics & Concepts
NeuraminidaseBiologyImmunogenicityVirologyVirusNeuraminidase inhibitorVaccinationOrthomyxoviridaeInfluenza vaccineInfluenza A virusMicrobiologyImmunologyAntibodyCoronavirus disease 2019 (COVID-19)MedicineInfectious disease (medical specialty)DiseasePathologyInfluenza Virus Research StudiesRespiratory viral infections researchViral Infections and Immunology Research