Immune correlates of tuberculosis disease and risk translate across species
Mushtaq Ahmed, Shyamala Thirunavukkarasu, Bruce A. Rosa, Kimberly A. Thomas, Shibali Das, Javier Rangel‐Moreno, Lan Lu, Smriti Mehra, Stanley Kimbung Mbandi, Larissa B. Thackray, Michael Diamond, Kenneth M. Murphy, Terry K. Means, John Martin, Deepak Kaushal, Thomas J. Scriba, Makedonka Mitreva, Shabaana A. Khader
Abstract
infection and translate into identifying immune pathways that mediate TB immunopathology in humans. Together, our cross-species findings provide insights into modeling TB disease and the immunological basis of TB disease progression.
Topics & Concepts
Immune systemDiseaseTuberculosisMacaqueImmunologyBiologyMedicineVirologyPathologyNeuroscienceTuberculosis Research and EpidemiologyCytokine Signaling Pathways and InteractionsMycobacterium research and diagnosis