Rhodium-catalyzed asymmetric transfer hydrogenation of 4-quinolone derivatives
Bin He, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal
Abstract
4-Quinolone derivatives were conveniently reduced to 1,2,3,4-tetrahydroquinoline-4-ols with excellent enantioselectivities through asymmetric transfer hydrogenation using a tethered rhodium complex and formic acid/triethylamine as the hydride source.
Topics & Concepts
RhodiumChemistryTransfer hydrogenationFormic acidTriethylamineHydrideCatalysisQuinoloneAsymmetric hydrogenationCombinatorial chemistryOrganic chemistryEnantioselective synthesisRutheniumHydrogenAntibioticsBiochemistryAsymmetric Hydrogenation and CatalysisSurface Chemistry and CatalysisChemical Synthesis and Analysis