Site-specific PEGylation of interleukin-2 enhances immunosuppression via the sustained activation of regulatory T cells
Bo Zhang, Jiaqi Sun, Yan Wang, Dezhong Ji, Yeshuang Yuan, Shengjie Li, Yeting Sun, Yingqin Hou, Pengchong Li, Lidan Zhao, Fei Yu, Wenxiao Ma, Boyang Cheng, Ling Wu, Jin Hu, Min Wang, Wei Song, Xiaogang Li, Hao Li, Yunyun Fei, Hua Chen, Lihe Zhang, George C. Tsokos, Demin Zhou, Xuan Zhang
Topics & Concepts
PEGylationCytokineImmunologyImmunosuppressionImmune systemChemistryInterleukin 2ImmunotherapyAutoimmunityAutoimmune diseaseCancer researchPharmacologyBiologyBiochemistryPolyethylene glycolAntibodyImmunotherapy and Immune ResponsesImmune Cell Function and InteractionT-cell and B-cell Immunology