Combined effects of aerobic exercise and 40-Hz light flicker exposure on early cognitive impairments in Alzheimer’s disease of 3×Tg mice
Sang-Seo Park, Hye-Sang Park, Chang‐Ju Kim, Seung‐Soo Baek, Song‐Young Park, Cody Anderson, Myung-Ki Kim, Ik-Ryeul Park, Tae-Woon Kim
Abstract
Exercising in a 40-Hz light flicker environment was more effective than exercise or 40-Hz light flicker alone. This synergistic effect may prevent cognitive dysfunction by inhibiting Aβ, tau pathway, and neuroinflammation and enhancing neuroplasticity and mitochondrial functions in the hippocampus during early Alzheimer's disease.
Topics & Concepts
NeuroinflammationHippocampusProinflammatory cytokineCognitive declineAlzheimer's diseaseNeuroscienceHippocampal formationPsychologyDementiaNeuroplasticityNeurodegenerationMedicineInternal medicineEndocrinologyDiseaseInflammationNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research