Persistence of Lgr5+ colonic epithelial stem cells in mouse models of inflammatory bowel disease
Nandini Girish, Cambrian Y. Liu, Safina Gadeock, Marie L. Gomez, Ying Huang, Zohreh Sharifkhodaei, M. Kay Washington, D. Brent Polk
2021American Journal of Physiology-Gastrointestinal and Liver Physiology24 citationsDOIOpen Access PDF
Abstract
Acute intestinal injury and epithelial repair are associated with the loss of fast-cycling Lgr5+ stem cells and plasticity in the activation of formerly quiescent cell populations. In contrast, here we show in murine inflammatory bowel disease the persistence of the Lgr5+ stem cell population and its essential role in restricting the severity of chronic colitis. This demonstrates a diversity of stem cell responses to colitis.
Topics & Concepts
LGR5Stem cellInflammatory bowel diseaseColitisBiologyImmunologyPopulationPersistence (discontinuity)Intestinal epitheliumInflammationEpitheliumDiseaseCell biologyMedicineCancer stem cellPathologyGeneticsEnvironmental healthEngineeringGeotechnical engineeringCancer Cells and MetastasisDigestive system and related healthCongenital gastrointestinal and neural anomalies