Hierarchically patterned protein scaffolds with nano-fibrillar and micro-lamellar structures modulate neural stem cell homing and promote neuronal differentiation
Jiaqi Hu, Chenlin Li, Zhangze Yang, Qi Wu, Jie Wang, Zongpu Xu, Yuyin Chen, Quan Wan, Yajun Shuai, Shuxu Yang, Mingying Yang
Abstract
This silk fibroin/graphene oxide-based scaffold with nano-fibrillar and micro-lamellar structures can effectively promote cell migration, adhesion, and proliferation, facilitating the differentiation of neural stem cells into neurons.
Topics & Concepts
Homing (biology)Neural stem cellCell biologyNano-ChemistryLamellar structureNanotechnologyBiophysicsStem cellMaterials scienceBiologyCrystallographyEcologyComposite material3D Printing in Biomedical ResearchGraphene and Nanomaterials ApplicationsNerve injury and regeneration