Silencing TRPM2 enhanced erastin- and RSL3-induced ferroptosis in gastric cancer cells through destabilizing HIF-1α and Nrf2 proteins
Dingyun Li, Ting Wang, Jiajun Lai, Deqiang Zeng, Weijuan Chen, Xiaochong Zhang, Xiao‐Feng Zhu, Guoxiong Zhang, Zhiwei Hu
Topics & Concepts
TRPM2Cancer cellGene knockdownOxidative stressCell biologyGene silencingCancer researchReactive oxygen speciesChemistryProgrammed cell deathBiologyApoptosisMolecular biologyCancerBiochemistryTransient receptor potential channelReceptorGeneticsGeneFerroptosis and cancer prognosisGenomics, phytochemicals, and oxidative stressCancer-related molecular mechanisms research