Effects of <scp>l</scp> -Serine on Macrolide Resistance in Streptococcus suis
Tong Wu, Xiaozhen Wang, Yue Dong, Chen Xing, Xueying Chen, Lu Li, Chunliu Dong, Yanhua Li
Abstract
The emergence of antimicrobial resistance is a global challenge. However, new drug development efforts consume considerable resources and time, and alleviating the pressure on existing drugs is the focus of our work. We investigated the mechanism of action of l-serine supplementation in restoring the use of macrolides in S. suis, based on the role of the serine catabolic pathway on reactive oxygen species levels and oxidative stress in S. suis. This pathway provides a theoretical basis for the rational use of macrolides in clinical practice and also identifies a possible target for restoring drug sensitivity in S. suis.
Topics & Concepts
Streptococcus suisSerineIntracellularMicrobiologyGlutathioneBiologyDrug resistanceCatabolismReactive oxygen speciesBiochemistryChemistryPharmacologyMetabolismPhosphorylationEnzymeVirulenceGeneStreptococcal Infections and TreatmentsInfections and bacterial resistanceOral microbiology and periodontitis research