Rhodium-catalyzed dearomative rearrangement of 2-oxypyridines with cyclopropenes: access to <i>N</i>-alkylated 2-pyridones
Honglian Cui, Guangyang Xu, Jie Zhu, Jiangtao Sun
Abstract
A novel rhodium-catalyzed dearomative rearrangement of oxo-pyridine derivatives has been realized, providing an efficient and reliable protocol for the synthesis of N -alkylated pyridones.
Topics & Concepts
ChemistryAlkylationRhodiumCatalysisMedicinal chemistryCombinatorial chemistryOrganic chemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions