Intestinal Injury Biomarkers Predict Mortality in Pediatric Severe Malaria
Maithri L Sarangam, Ruth Namazzi, Dibyadyuti Datta, Caitlin Bond, Charles Vanderpool, Robert O. Opoka, Chandy C. John, Andrea L. Conroy
Abstract
In children with severe malaria, intestinal injury is a common complication associated with increased mortality. Intestinal injury is associated with acute kidney injury, acidosis, and endothelial activation. Interventions promoting intestinal regeneration and repair represent novel approaches to improve outcomes.
Topics & Concepts
MalariaMedicineIntensive care medicineImmunologySepsis Diagnosis and TreatmentLiver Disease Diagnosis and TreatmentMalaria Research and Control