Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency
Jiajing Zhang, Xiaoqian Yuan, Hongsen Li, Liting Yu, Yulong Zhang, Keyi Pang, Chaoyue Sun, Zhongyang Liu, Jie Li, Liying Ma, Jinming Song, Lingxin Chen
Abstract
chronic wound healing experiments proved that the antibacterial and anti-inflammatory effect of the PCTL group was the best, further confirmed by H&E histological analysis, immunofluorescence and immunohistochemistry mechanism experiments. This research lays the foundation for the manufacture of novel molecules that combine chemical and photodynamic strategies.
Topics & Concepts
PorphyrinPhotosensitizerAntimicrobialChemistrySalt (chemistry)Staphylococcus aureusPhotodynamic therapyCombinatorial chemistryDerivative (finance)AmmoniumAntibacterial activityNuclear chemistryPhotochemistryOrganic chemistryBacteriaBiologyEconomicsGeneticsFinancial economicsPhotodynamic Therapy Research StudiesPorphyrin and Phthalocyanine ChemistryNanoplatforms for cancer theranostics