β cell aging and age-related diabetes
Min Zhu, Xiaohong Liu, Wen Liu, Yanrong Lu, Jingqiu Cheng, Younan Chen
Abstract
Type 2 diabetes is characterized by insulin resistance and loss of β cell mass and function. Aging is considered as a major risk factor for development of type 2 diabetes. However, the roles of pancreatic β cell senescence and systemic aging in the pathogenesis of type 2 diabetes in elderly people remain poorly understood. In this review, we aimed to discuss the current findings and viewpoints focusing on β cell aging and the development of type 2 diabetes.
Topics & Concepts
Type 2 diabetesDiabetes mellitusInsulin resistanceSenescencePathogenesisMedicineViewpointsBioinformaticsGerontologyInternal medicineBiologyEndocrinologyVisual artsArtPancreatic function and diabetesDiet, Metabolism, and DiseaseDiabetes and associated disorders