Engineered mesenchymal stem cell-derived exosomes with high CXCR4 levels for targeted siRNA gene therapy against cancer
Shuyue Xu, Bin Liu, Junyi Fan, Cuili Xue, Yi Lu, Can Li, Daxiang Cui
Abstract
and thereby inhibiting tumour growth. This new gene-drug delivery system has tremendous clinical transformation value and provides a new strategy for clinical treatment of tumours.
Topics & Concepts
Genetic enhancementMicrovesiclesMesenchymal stem cellCancer researchSurvivinGene deliveryHoming (biology)Cancer cellStromal cellCancer stem cellTargeted therapyBiologyStem cellCancermicroRNACell biologyGeneBiochemistryEcologyGeneticsExtracellular vesicles in diseaseRNA Interference and Gene DeliveryMesenchymal stem cell research