Multi-pronged molecular insights into flavonoid-mediated inhibition of squalene epoxidase: a pathway to novel therapeutics
Emadeldin M. Kamel, Sarah I. Othman, Hassan A. Rudayni, Ahmed A. Allam, Al Mokhtar Lamsabhi
Abstract
predictions and experimental results underscores the reliability of computational approaches in drug discovery, paving the way for future preclinical development of these compounds as novel SQLE-targeted therapeutics.
Topics & Concepts
Squalene monooxygenaseSilibininBaicalinSqualeneChemistryIn silicoAntifungalFlavonoidPharmacologyComputational biologyBiochemistryMedicineEnzymeBiologyMicrobiologyBiosynthesisAntioxidantChromatographyGeneHigh-performance liquid chromatographyPlant biochemistry and biosynthesisNatural Antidiabetic Agents StudiesSphingolipid Metabolism and Signaling