One-pot three-component synthesis of isoxazole using ZSM-5 as a heterogeneous catalyst
Navnath T. Hatvate, Shrikant M. Ghodse
Abstract
A mild and convenient route for the synthesis of isoxazole derivatives has been developed using ZSM-5 as a heterogeneous catalyst. The reaction was carried out under a solvent-free condition to afford the desired products in good yields. A variety of functional groups was tolerated under the reaction conditions employed. Moreover, the heterogeneous catalyst (ZSM-5) was recovered and reused several times without significant loss of its catalytic activity.
Topics & Concepts
IsoxazoleChemistryCatalysisZSM-5Component (thermodynamics)SolventHeterogeneous catalysisReaction conditionsOrganic chemistryCombinatorial chemistryZeoliteThermodynamicsPhysicsMulticomponent Synthesis of HeterocyclesChemical Synthesis and ReactionsMicrowave-Assisted Synthesis and Applications