Regiodivergent Synthesis of Spirocyclic Compounds through Pd‐Catalyzed Regio‐ and Enantioselective [3+2] Spiroannulation
Barry M. Trost, Zhijun Zuo
Abstract
-catalyzed highly regio- and enantioselective [3+2] spiroannulation reaction has been developed for rapid assembly of a new class of [5,5] spirocyclic carbo- and heterocycles. Notably, the regioselectivity could be dominated by fine-tuning of the Pd-π-allyl intermediate. An array of coupling partners could be well-tolerated with excellent regio-, and enantioselectivities. Moreover, the potential application of this reaction was exemplified by several further transformations.
Topics & Concepts
RegioselectivityEnantioselective synthesisCatalysisChemistryCombinatorial chemistryPalladiumStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthetic Organic Chemistry MethodsCyclopropane Reaction Mechanisms