Synthesis of <i>N</i>-perfluoroalkyl-3,4-disubstituted pyrroles by rhodium-catalyzed transannulation of <i>N</i>-fluoroalkyl-1,2,3-triazoles with terminal alkynes
Olga Bakhanovich, Viktor V. Khutorianskyi, Vladimir Motornov, Petr Beier
Abstract
The rhodium-catalyzed transannulation of N- perfluoroalkyl-1,2,3-triazoles with aromatic and aliphatic terminal alkynes under microwave heating conditions afforded N- perfluoroalkyl-3,4-disubstituted pyrroles (major products) and N- fluoroalkyl-2,4-disubstituted pyrroles (minor products). The observed selectivities in the case of the reactions with aliphatic alkynes were high.
Topics & Concepts
RhodiumChemistryCatalysisTerminal (telecommunication)AlkynylationMedicinal chemistryOrganic chemistryCombinatorial chemistryTelecommunicationsComputer scienceFluorine in Organic ChemistryCyclopropane Reaction MechanismsClick Chemistry and Applications