Genetics of Intracranial Aneurysms
Mark K. Bakker, Ynte M. Ruigrok
Abstract
Rupture of an intracranial aneurysm leads to aneurysmal subarachnoid hemorrhage, a severe type of stroke which is, in part, driven by genetic variation. In the past 10 years, genetic studies of IA have boosted the number of known genetic risk factors and improved our understanding of the disease. In this review, we provide an overview of the current status of the field and highlight the latest findings of family based, sequencing, and genome-wide association studies. We further describe opportunities of genetic analyses for understanding, prevention, and treatment of the disease.
Topics & Concepts
MedicineSubarachnoid hemorrhageAneurysmDiseaseGenome-wide association studyStroke (engine)Genetic variationGenetic associationGenetic variantsBioinformaticsIntensive care medicineGenotypeSurgeryInternal medicineGeneticsSingle-nucleotide polymorphismGeneEnvironmental healthEngineeringMechanical engineeringPopulationBiologyIntracranial Aneurysms: Treatment and ComplicationsMoyamoya disease diagnosis and treatmentIntracerebral and Subarachnoid Hemorrhage Research