Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma
Anna Han, Vivian Chua, Usman Baqai, Timothy J. Purwin, Nelisa Bechtel, Emily Hunter, Manoela Tiago, Erin Seifert, David W. Speicher, Zachary T. Schug, J. William Harbour, Andrew E. Aplin
Topics & Concepts
BAP1GlycolysisMutantPyruvate dehydrogenase complexBiologyCancer researchPyruvate kinaseMelanomaDownregulation and upregulationPhosphorylationPKM2PhenotypeCellMolecular biologyKinasePyruvate dehydrogenase kinasePyruvate dehydrogenase phosphataseCell cycleProtein kinase ACell biologyEnzymePyruvate dehydrogenase lipoamide kinase isozyme 1Cell cultureBiochemistryOcular Oncology and TreatmentsCancer, Hypoxia, and MetabolismCancer Research and Treatments