Allelic frequencies of mutants of the Plasmodium falciparum, quinoline and folate metabolizing genes in the west region of Cameroon
Innocent Mbulli Ali, Valery Pacome Kom Tchuenkam, Sandra Sob Tagomo, Hornela Mawamba, Marcel N. Moyeh, Emmanuel Nfor Nfor, Akindeh M. Nji, Calvino Tah Fomboh, William Dorian Nana, Jean-Paul Chedjou Kengne, Peter Thelma Ngwa Niba, Germaine Ekobo Ekoyol, Dorothy Fosah Achu, Jude D. Bigoga, Wilfred Fon Mbacham
Abstract
) loci which may reflect possible drug-related selection of this mutant in the parasite population. Continuous monitoring of these mutations is recommended to pre-empt a loss in sulphadoxine-pyrimethamine efficacy in malaria chemoprevention programs.
Topics & Concepts
AlleleMalariaBiologyPlasmodium falciparumHaplotypeGeneticsGeneDrug resistanceDihydropteroate synthasePyrimethamineImmunologyMalaria Research and ControlHIV/AIDS drug development and treatmentParasites and Host Interactions