CBX2 and EZH2 cooperatively promote the growth and metastasis of lung adenocarcinoma
Feifei Hu, Hao Chen, Yang Duan, Bei Lan, Chunjie Liu, Hui Hu, Dong Xu, Qiong Zhang, Yiming Cheng, Min Liu, An‐Yuan Guo, Chenghao Xuan
Abstract
. The combined high expression of CBX2 and EZH2 was an indicator of poor prognosis in LUAD. The inhibition of both CBX2 and EZH2 exerted cooperative suppressive effects on the growth and metastasis of LUAD cells. Mechanistically, we revealed that CBX2 and EZH2 downregulated several PPAR signaling pathway genes and tumor suppressor genes through binding to their promoter cooperatively or separately. Furthermore, knockdown of CBX2 improved the therapeutic efficiency of EZH2 inhibitor on A549 cells. Our study reveals the cooperative oncogenic role of CBX2 and EZH2 in promoting LUAD progression, thereby providing potential targets for LUAD diagnosis and therapy.