AMPK activation in pregnant human myometrial arteries from high-altitude and intrauterine growth-restricted pregnancies
Ramón A. Lorca, Christopher J. Matarazzo, Elise S. Bales, Julie A. Houck, David J. Orlicky, Anna G. Euser, Colleen G. Julian, Lorna G. Moore
Abstract
Intrauterine growth restriction (IUGR) impairs infant well- being and increases susceptibility to later-in-life diseases for mother and child. Our study reveals a novel role for AMPK in vasodilating the myometrial artery (MA) from women residing at high altitude (>2,500 m) with appropriate for gestational age pregnancies but not in IUGR pregnancies at any altitude.
Topics & Concepts
Intrauterine growth restrictionMedicineAMPKGestationObstetricsPregnancyVasodilationEffects of high altitude on humansEndocrinologyBiologyAnatomyBiochemistryGeneticsEnzymeProtein kinase APregnancy and preeclampsia studiesBirth, Development, and HealthGestational Diabetes Research and Management