Hypoxia-inducible factor protects against acute kidney injury via the Wnt/β-catenin signaling pathway
Zhihui Xu, Chang Wang, Yixin He, Xinyue Mao, Man-Zhu Zhang, Yanpei Hou, Bing Li
Abstract
We investigated the role of hypoxia-inducible factor (HIF) in acute kidney injury in vivo and in vitro. Expression of HIF in the adaptive repair group was more rapid and sufficient than that in the maladaptive repair group during the early repair phase. HK-2 and EA.hy926 cells treated with hypoxia/reoxygenation were used to elucidate the cross talk between HIF and the Wnt/β-catenin signaling pathway by which HIF played a renoprotective role in acute kidney injury.
Topics & Concepts
Wnt signaling pathwayGene silencingDownregulation and upregulationHypoxia (environmental)Cancer researchAcute kidney injuryHypoxia-inducible factorsKidneyGene knockdownApoptosisSignal transductionCell biologyMedicineBiologyInternal medicineChemistryGeneOxygenOrganic chemistryBiochemistryCancer, Hypoxia, and MetabolismAcute Kidney Injury ResearchHigh Altitude and Hypoxia