π‐Extended Donor–Acceptor Porphyrins and Metalloporphyrins for Antimicrobial Photodynamic Inactivation
Anzhela Galstyan, Yogesh Kumar Maurya, Halina Zhylitskaya, Youn Jue Bae, Yi‐Lin Wu, Michael R. Wasielewski, Tadeusz Lis, Ulrich Dobrindt, Marcin Stępień
Abstract
Free base, zinc and palladium π-extended porphyrins containing fused naphthalenediamide units were employed as photosensitizers in antimicrobial photodynamic therapy (aPDT). Their efficacy, assessed by photophysical and in vitro photobiological studies on Gram-positive bacteria, was found to depend on metal coordination, showing a dramatic enhancement of photosensitizing activity for the palladium complex.
Topics & Concepts
Photodynamic therapyAntimicrobialChemistryPalladiumZincPhotosensitizerPhotochemistryCombinatorial chemistryAcceptorMetalFree baseIn vitroOrganic chemistryBiochemistryCatalysisPhysicsCondensed matter physicsSalt (chemistry)Porphyrin and Phthalocyanine ChemistryPhotodynamic Therapy Research StudiesNanoplatforms for cancer theranostics