Capillary Electrophoresis-Mass Spectrometry at Trial by Metabo-Ring: Effective Electrophoretic Mobility for Reproducible and Robust Compound Annotation
Nicolas Drouin, Marlien van Mever, Wei Zhang, Elena Tobolkina, Sabrina Ferré, Anne‐Catherine Servais, Marie‐Jia Gou, Laurent Nyssen, Marianne Fillet, Guinevere S. M. Lageveen‐Kammeijer, Jan Nouta, Andrew J. Chetwynd, Iseult Lynch, James A. Thorn, Jens Meixner, Christopher Lößner, Myriam Taverna, Sylvie Liu, Nguyet Thuy Tran, Yannis‐Nicolas François, Antony Lechner, Reine Nehmé, Ghassan Al Hamoui Dit Banni, Rouba Nasreddine, Cyril Colas, Herbert Lindner, Klaus Faserl, Christian Neusüß, Manuel Nelke, Stefan Lämmerer, Catherine Perrin, Claudia Bich, Coral Barbas, Ángeles López‐Gonzálvez, András Guttman, Márton Szigeti, Philip Britz‐McKibbin, Zachary Kroezen, Meera Shanmuganathan, Péter Nemes, Erika P. Portero, Thomas Hankemeier, Santiago Codesido, Víctor González‐Ruiz, Serge Rudaz, Rawi Ramautar
Abstract
for 20 out of the 21 model compounds was below 3.1% vs 10.9% for RMT, regardless of the huge heterogeneity in experimental conditions and platforms across the 13 laboratories. Overall, this Metabo-ring trial demonstrated that CE-MS is a viable and reproducible approach for metabolomics.