Lymphopenia in sepsis: a narrative review
Zhibin Wang, Wenzhao Zhang, Linlin Chen, Xin Lü, Ye Tu
Abstract
This narrative review provides an overview of the evolving significance of lymphopenia in sepsis, emphasizing its critical function in this complex and heterogeneous disease. We describe the causal relationship of lymphopenia with clinical outcomes, sustained immunosuppression, and its correlation with sepsis prediction markers and therapeutic targets. The primary mechanisms of septic lymphopenia are highlighted. In addition, the paper summarizes various attempts to treat lymphopenia and highlights the practical significance of promoting lymphocyte proliferation as the next research direction.
Topics & Concepts
MedicineSepsisNarrative reviewNarrativeIntensive care medicineInternal medicineLiteratureArtSepsis Diagnosis and TreatmentHematological disorders and diagnosticsThermal Regulation in Medicine