Deregulation of ribosomal proteins in human cancers
Wendy El Khoury, Zeina Nasr
Abstract
The ribosome, the site for protein synthesis, is composed of ribosomal RNAs (rRNAs) and ribosomal proteins (RPs). The latter have been shown to have many ribosomal and extraribosomal functions. RPs are implicated in a variety of pathological processes, especially tumorigenesis and cell transformation. In this review, we will focus on the recent advances that shed light on the effects of RPs deregulation in different types of cancer and their roles in regulating the tumor cell fate.
Topics & Concepts
Ribosomal proteinBiologyRibosomal RNACarcinogenesisCancerGeneticsCellCell biologyRibosomeRibosomal DNAComputational biology30SRNACell typeCancer cellTumor cellsP53 proteinCell growthRNA modifications and cancerRNA and protein synthesis mechanismsPARP inhibition in cancer therapy