Engineering CAR-NK cells targeting CD33 with concomitant extracellular secretion of anti-CD16 antibody revealed superior antitumor effects toward myeloid leukemia
Rui Zhang, Qingxi Liu, Sa Zhou, Hongpeng He, Mingfeng Zhao, Wenjian Ma
Topics & Concepts
Myeloid leukemiaCD33Cancer researchCD16ImmunologyLeukemiaAntibodyInterleukin 12BiologyImmune systemChemistryCytotoxic T cellCell biologyIn vitroStem cellCD34CD8BiochemistryCD3Immune Cell Function and InteractionCAR-T cell therapy researchT-cell and B-cell Immunology