Enteroendocrine cells regulate intestinal barrier permeability
Jennifer Nwako, Sparsh D. Patel, Taevon J. Roach, Saanvi R. Gupte, Samara G. Williams, Anne Marie Riedman, Heather A. McCauley
Abstract
There are no therapies that directly improve the permeability of the intestinal epithelial barrier. This work uses a human intestinal epithelial model system to demonstrate that sensory enteroendocrine cells are necessary for healthy barrier function and that two of their secreted products, peptide YY and somatostatin, are sufficient to improve barrier function at homeostasis and in the presence of inflammatory cytokines. This could provide novel treatments for strengthening the epithelial barrier in human gastrointestinal disease.
Topics & Concepts
Barrier functionOccludinEnteroendocrine cellTight junctionParacellular transportCell biologyBiologyIntestinal permeabilityIntestinal epitheliumCytokineImmunologyEndocrinologyEndocrine systemEpitheliumHormonePermeability (electromagnetism)BiochemistryGeneticsMembraneBarrier Structure and Function StudiesGut microbiota and healthConnexins and lens biology