Copper-Catalyzed Direct Carbonylation of Carbenes toward the Synthesis of Propanedioic Acid Derivatives
Hefei Yang, Zhipeng Bao, Le‐Cheng Wang, Xiao‐Feng Wu
Abstract
Carbenes are highly active reaction intermediates, which can be used as reaction precursors to modify organisms, drugs, and material molecules. In this work, we realized a new cheap metal-catalyzed carbonylation of carbene to give propanedioic acid derivatives. With copper salt as the catalyst, synthetically important malonates and related compounds were produced in good yields under mild reaction conditions.
Topics & Concepts
ChemistryCatalysisCarbonylationCarbeneCopperSalt (chemistry)Combinatorial chemistryMoleculeOrganic chemistryMetalCarbon monoxideCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions