Efficient cocrystal coformer screening based on a Machine learning Strategy: A case study for the preparation of imatinib cocrystal with enhanced physicochemical properties
Xiaoxiao Liang, Shiyuan Liu, Zebin Li, Yuehua Deng, Yanbin Jiang, Huaiyu Yang
Topics & Concepts
CocrystalSolubilityActive ingredientChemistryImatinib mesylateDissolutionCombinatorial chemistryImatinibNanotechnologyMaterials scienceOrganic chemistryPharmacologyHydrogen bondMyeloid leukemiaMoleculeImmunologyBiologyMedicineCrystallography and molecular interactionsCrystallization and Solubility StudiesCrystal structures of chemical compounds