Genomic description of acquired fluconazole- and echinocandin-resistance in patients with serial <i>Candida glabrata</i> isolates
Elizabeth Misas, Emma E. Seagle, E. N. Jenkins, Malavika Rajeev, Steven F. Hurst, Natalie S. Nunnally, Michael L. Bentz, Meghan Lyman, Elizabeth L. Berkow, Lee H. Harrison, William Schaffner, Tiffanie Markus, Rebecca Pierce, Monica M. Farley, Nancy A. Chow, Shawn R. Lockhart, Anastasia P. Litvintseva
Abstract
In our study, mutations associated to azole resistance and echinocandin resistance were detected in Candida glabrata isolates using a whole-genome sequence. C. glabrata is the second most common cause of candidemia in the United States, which rapidly acquires resistance to antifungals, in vitro and in vivo .
Topics & Concepts
Candida glabrataEchinocandinFluconazoleMicrobiologyBiologyFungemiaDrug resistanceAzoleFungi imperfectiAntifungalAntifungal resistance and susceptibilityFungal Infections and StudiesPneumocystis jirovecii pneumonia detection and treatment