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Topology-dependent interference of synthetic gene circuit function by growth feedback

Rong Zhang, Jiao Li, Juan Melendez-Alvarez, Xingwen Chen, Patrick Sochor, Hanah Goetz, Qi Zhang, Tian Ding, Xiao Wang, Xiao‐Jun Tian

2020Nature Chemical Biology68 citationsDOIOpen Access PDF

Topics & Concepts

BistabilityElectronic circuitTopology (electrical circuits)Negative feedbackSynthetic biologyPositive feedbackComputer scienceDecoupling (probability)Network topologyGene regulatory networkBiological systemBiologyGeneMaterials sciencePhysicsMathematicsGene expressionBioinformaticsGeneticsOptoelectronicsCombinatoricsVoltageControl engineeringOperating systemElectrical engineeringQuantum mechanicsEngineeringGene Regulatory Network AnalysisSingle-cell and spatial transcriptomicsReceptor Mechanisms and Signaling
Topology-dependent interference of synthetic gene circuit function by growth feedback | Litcius